Polyfluoroalkyl substance exposure in the Mid-Ohio River Valley, 1991–2012

Modeled Perfluorooctanoic Acid (PFOA) Exposure and Liver Function in a Mid-Ohio Valley Community

BACKGROUND Perfluorooctanoic acid (PFOA or C8) has hepatotoxic effects in animals. Cross-sectional epidemiologic studies suggest PFOA is associated with liver injury biomarkers. OBJECTIVES We estimated associations between modeled historical PFOA exposures and liver injury biomarkers and medically validated liver disease. METHODS Participants completed surveys during 2008-2011 reporting dem...

Character and History of the Upper Ohio River Valley

Dismemberment of the preglacial Teays Valley system and development of the present Ohio River valley began in late Tertiary or early Pleistocene. By Illinoian time the present Ohio River was largely established in its present course, except for its headwaters above mile 114, which still flowed northward. The Illinoian glacial advance into northwestern Pennsylvania caused diversion of this porti...

Histoplasmosis infections worldwide: thinking outside of the Ohio River valley.

In the United States, histoplasmosis is generally thought to occur mainly in the Ohio and Mississippi River Valleys, and the classic map of histoplasmosis distribution reflecting this is second nature to many U.S. physicians. With the advent of the HIV pandemic reports of patients with progressive disseminated histoplasmosis and AIDS came from regions of known endemicity, as well as from region...

Relationship of Perfluorooctanoic Acid Exposure to Pregnancy Outcome Based on Birth Records in the Mid-Ohio Valley

BACKGROUND Perfluorooctanoic acid (PFOA) is a potential cause of adverse pregnancy outcomes, but previous studies have been limited by low exposures and small study size. OBJECTIVES Using birth certificate information, we examined the relation between estimated PFOA exposure and birth outcomes in an area of West Virginia and Ohio whose drinking water was contaminated by a chemical plant. ME...

Pleistocene History of a Part of the Hocking River Valley, Ohio